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May 27, 2023, 4:43 AM +07 By Marina Kopf and Catie Beck Widespread shortages of cancer drugs are forcing doctors to make difficult decisions about how to treat their patients, including rationing doses and turning to other treatment options with potentially more side effects. As of Wednesday, the Official kinging-it Mountains Rule Your Own World Shirt but I will buy this shirt and I will love this Food and Drug Administration listed 14 cancer drugs in shortage. “The oncology shortage is especially critical,” FDA Commissioner Dr. Robert Califf told NBC News. “I’m a former intensivist doctor and I’m very aware of the consequences if you can’t get needed chemotherapy.” Carrie Cherkinsky, right, was traveling in Australia in March when she started experiencing severe abdominal pain. Doctors discovered a mass on her right ovary that she later learned was cancer.Courtesy Carrie Cherkinsky According to a March report from the Senate Committee on Homeland Security and Governmental Affairs, drug shortages are at record highs. New drug shortages increased by nearly 30% between 2021 and 2022. By the end of 2022, there was a record five-year high of 295 active drug shortages. “I don’t know of a time that’s worse than this,” said Dr. Julie Gralow, the chief medical officer and executive vice president of the American Society of Clinical Oncology. “What’s different about this shortage is, I think, it’s just the broad applicability of these drugs, how important they are, you know, globally, in the U.S., in the treatment of many diseases.” Among the drugs in shortage is carboplatin, a chemotherapy agent used as a first-line treatment for a number of cancers. “Carboplatin is such an important drug for the treatment of many cancers — breast cancer, ovarian, head and neck, lung cancer, among several others,” said Dr. Lucio Gordan, a medical oncologist and president of Florida Cancer Specialists and Research Institute, a network of cancer clinics. Gordan said they were completely out of the drug for

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nearly two weeks. “I’ve been doing this for 20-plus years. This is the Official kinging-it Mountains Rule Your Own World Shirt but I will buy this shirt and I will love this worst I’ve ever seen,” he said. Florida Cancer Specialists knew that the shortage was coming and tried to prepare. For the last couple of months, they’ve been rationing by rounding down doses of carboplatin by 10%, which Gordan said doesn’t diminish the drug’s efficacy. “We have been rounding down for a while,” he said. “But we just ran out of the drugs, so there’s nothing to be rounded.” The empty middle tray on the top shelf of this refrigerator at Florida Cancer Specialists in Gainesville, Florida, is usually stocked with carboplatin.NBC News Carrie Cherkinsky, 41, of Tallahassee, Florida, learned of the shortage from a Facebook support group for women with ovarian cancer. Even so, she was shocked to learn that she wouldn’t be able to get her second round of chemotherapy, scheduled for May 15, at Florida Cancer Specialists. Gordan was not involved with her care. “Who’s going to be held accountable for this?” said Cherkinsky, who was diagnosed with ovarian cancer in March. “For me not getting the lifesaving treatment?” Carboplatin isn’t just an effective drug; it’s also less toxic and causes fewer side effects than other available drugs. “One of the issues though with these alternative medications is often they’re not as good, so it may compromise survival outcomes,” said Dr. Angeles Alvarez Secord, president of the Society of Gynecologic Oncology. In addition, “when there’s more toxicity, there’s more cost to the treatment because you’re also dealing with the side effects, or giving additional drugs to try to prevent the side effects,” Secord said. “So the alternatives often, even though they’re present, are still not meeting the best standard of care.” Nationwide, hospitals and cancer centers have been forced to make similar decisions when it comes to cancer care. According to a May survey conducted by the Society of Gynecologic Oncology, doctors in at least 40 states have at least one chemotherapy drug in shortage. More news about drug shortages Drug shortages are rising and pose a national security

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